Synthesis of peptides containing methylated Lysine residues

Post-translational methylation of histone lysine residues is emerging as an important control mechanism for the regulation of protein expression, X chromosome activation, genomic imprinting and DNA repair. We successfully synthesised Fmoc-Lys(Me,Boc-OH, Fmoc-Lys(Me)2-OH and Fmoc-Lys(Me)3-OH and implied into Solid phase peptide synthesis.
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