| Name
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[DArg1,DPhe5,DTrp7,9,Leu11] Substance P
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| Code
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[96736-12-8]
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| The alias
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[DArg1,DPhe5,DTrp7,9,Leu11] Substance P
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| Sequence (single letter abbreviation)
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rPKPfQwFwLL-NH2
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| Sequence (three-letter abbreviation)
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H-DArg-Pro-Lys-Pro-DPhe-Gln-DTrp-Phe-DTrp-Leu-Leu-NH2?(trifluoroacetate salt)
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| A basic description
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This neuropeptide was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. It contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation.
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| solubility
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| The molecular weight
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1516.86
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| Chemical formula
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C79H109N19O12
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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B.Holst et al., Mol. Endocrinol., 17, 2201 (2003)
D.A.Jones et al., Peptides, 16, 777 (1995)
J.G.Reeve and N.M.Bleehen, Biochem. Biophys. Res. Commun., 199, 1313 (1994)
H.Houben and C.Denef, Peptides, 14, 109 (1993)
P.J.Woll and E.Rozengurt, Proc. Natl. Acad. Sci. USA, 85, 1859 (1988)
K.Tsou et al., Eur. J. Pharmacol., 110, 155 (1985)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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