| Name
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RGD-4C
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| Code
|
|
| The alias
|
RGD-4C
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| Sequence (single letter abbreviation)
|
ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)
|
| Sequence (three-letter abbreviation)
|
H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH (trifluoroacetate salt)(Disulfide bridge: 2-10 and 4-8)
|
| A basic description
|
This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids.
|
| solubility
|
|
| The molecular weight
|
1145.3
|
| Chemical formula
|
C42H60N14O16S4
|
| The purity
|
80%，90%，95%，98%，99%
|
| Weight
|
1mg,5mg,10mg,50mg,100mg,1g
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
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| Documents
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| Figures
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|
| Reference
|
Curnis, F. et al. Cancer Res. 64, 565 (2004)
Su, Z. et al. Bioconjug. Chem. 13, 561 (2002)
Gerlag, M. et al. Arthritis Res. 3, 357 (2001)
Ellerby, H. et al. Nature Med. 5, 1032 (1999)
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| The C-terminal
|
|
| The N-terminal
|
|
| Chemical bridge
|
(Disulfide bridge: 2-10 and 4-8)
|