| Name
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(Ac-LEHD-AFC )
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| Code
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[210345-03-2]
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| The alias
|
(Ac-LEHD-AFC )
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| Sequence (single letter abbreviation)
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Ac-LEHD-AFC
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| Sequence (three-letter abbreviation)
|
Ac-Leu-Glu-His-Asp-AFC
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| A basic description
|
Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).
|
| solubility
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|
| The molecular weight
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765.7
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| Chemical formula
|
C33H38F3N7O11
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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R.Moriya et al., FEBS Lett. , 484, 253 (2000)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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