| Name
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Amyloid beta/A4 Protein Precursor770 (135-
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| Code
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[315229-44-8]
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| The alias
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Amyloid beta/A4 Protein Precursor770 (135-
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| Sequence (single letter abbreviation)
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FLHQERMDVCETHLHWHTVAK
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| Sequence (three-letter abbreviation)
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H-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH (trifluoroacetate salt)
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| A basic description
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This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid beta-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid beta-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
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| solubility
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| The molecular weight
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2618
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| Chemical formula
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C116H173N35O31S2
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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G.Multhaup et al., Science, 271, 1406 (1996)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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