| Name
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[Lys(Ac)382]-p53 (368-393), p53 K382(Ac), biotin-labeled, human
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| Code
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| The alias
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[Lys(Ac)382]-p53 (368-393), p53 K382(Ac), biotin-labeled, human
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| Sequence (single letter abbreviation)
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Biotin-KGGHLKSKKGQSTSRHK-K(Ac)-LMFKTEGPDSD-NH2
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| Sequence (three-letter abbreviation)
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Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys(Ac)-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2(trifluoroacetate salt)
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| A basic description
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This peptide is derived from amino acid residues 372-389 of human p53 tumor suppressor protein and is acetylated at Lys382. It is biotinylated at its N-terminus through a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
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| solubility
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| The molecular weight
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3481
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| Chemical formula
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Ghosh, A. et al. Mol. Cell Biol. 24, 7987 (2004)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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