| Name
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[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human
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| Code
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| The alias
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[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human
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| Sequence (single letter abbreviation)
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Biotin-KGWHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2
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| Sequence (three-letter abbreviation)
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Biotin-Lys-Gly-Trp-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2(trifluoroacetate salt)
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| A basic description
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This is an amidated peptide derived from residues 361-393 of human p53 tumor suppressor protein with acetylation at Lys382. This peptide is biotin-labeled at its N-terminus with a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo
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| solubility
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| The molecular weight
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3610.2
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| Chemical formula
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
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Kubbutat, M. et al. Lett Nature 387, 299 (1997)
Li, M. et al. J Biol Chem 277, 50607 (2002)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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