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[Ser140]-Myelin Proteolipid Protein (139-151) (Depalmitoylated), Bovine, Dog, Human, Mouse, Rat
| Name
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[Ser140]-Myelin Proteolipid Protein (139-151) (Depalmitoylated), Bovine, Dog, Human, Mouse, Rat
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| Other Name
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PLP
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| Sequence (Single letter abbreviations)
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HSLGKWLGHPDKF
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| Sequence（Three letter abbreviations）
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{HIS}{SER}{LEU}{GLY}{LYS}{TRP}{LEU}{GLY}{HIS}{PRO}{ASP}{LYS}{PHE}
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| Basic description
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Myelin proteolipid protein is the major myelin protein from the central nervous system (CNS). Myelin proteolipid protein probably plays an important role in the formation or maintenance of the multilamellar structure of myelin. In man point mutations in PLP are the cause of Pelizaeus-Merzbacher disease (PMD), a neurologic disorder of myelin metabolism. In animals dismyelinating diseases such as mouse 'jimpy' (jp), rat md, or dog 'shaking pup' are also caused by mutations in PLP. PLP is a ly conserved hydrophobic protein of 276 to 280 amino acids which seems to contain four transmembrane segments, two disulphide bonds and which covalently binds lipids (at least six palmitate groups in mammals). PLP is ly related to M6, a neuronal membran glycoprotein.
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| The molecular weight
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1521.740
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| Chemical formula
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C72H104N20O17
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| The purity
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> 95%
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| Storage conditions
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The peptide is stored at -20°C
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| Annotation
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| Documents
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| Figures
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| Reference
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Swanton E, et al. Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. Mar 2005; 102(12): 4342-4327.
Gudz TI, et al. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. J. Neurosci. Mar 2006; 26(9): 2458-2466.
Khan RS., etc. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells. Front Cell Neurosci. 2012 Dec;663.
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