| Name
|
Γ-2-MSH (41-58), Amide
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
YVMGHFRWDRFG
|
| Sequence（Three letter abbreviations）
|
{Tyr}{Val}{Met}{Gly}{His}{Phe}{Arg}{Trp}{Asp}{Arg}{Phe}{Gly}
|
| Basic description
|
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. more of the cells responding to 3-MSH express more than one pituitary hormone mRNA. The effect of 3-MSH is blocked by SHU9119, a MC3R and MC4R antagonist, in only 50% of the responsive cells, suggesting that in half of these cells the mediating receptor is not the MC3R. Low picomolar doses of 3-MSH increase [Ca2+]i in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line.
|
| The molecular weight
|
1570.780
|
| Chemical formula
|
C74H99N21O16S
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C.
|
Γ-2-MSH (41-58), Amide
