| Name
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Γ-1-Melanocyte Stimulating Hormone (MSH), Amide
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| Other Name
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γ-1-MSH, amide;γ1-MSH; g-1-MSH; g1-MSH; gamma-1-MSH; gamma1-MSHγ-1-Melanocyte Stimulating Hormone; γ1-Melanocyte Stimulating Hormone; g-1-Melanocyte Stimulating Hormone; g1-Melanocyte Stimulating Hormone; gamma-1-Melanocyte Stimulating Hormone; gamma1-Melanocyte Stimulating Hormone
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| Sequence (Single letter abbreviations)
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YVMGHFRWDRF-NH2
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| Sequence（Three letter abbreviations）
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{TYR}{VAL}{MET}{GLY}{HIS}{PHE}{ARG}{TRP}{ASP}{ARG}{PHE}-NH2
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| C-port
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NH2
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| Basic description
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Gamma-MSH (Melanocyte Stimulating Hormone), a putative hormone in the N-terminal region of the ACTH/beta- endorphin (beta-EP) precursor protein, was studied by RIA with an antiserum against gamma 3-MSH in ACTH-producing mouse pituitary tumor cells, AtT-20/D16v. Gamma-MSH peptides have low intrinsic melanotropic activity in mammalian melanoma cells; the specific pigmentary responses appear to be affected by the structure of the C-terminal portion.
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| The molecular weight
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1512.900
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| Chemical formula
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C72H97N21O14S1
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| The purity
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> 95%
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| Storage conditions
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Store the peptide at -20°C. Keep container tightly closed.
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| Annotation
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Gamma-1-MSH is derived from ACTH 1-13. Gamma-1-MSH is a hormone that stimulates melanogenesis and facilitates learning and memory. Gamma-1-MSH can affect inflammatory and immune responses and peripheral nerve regeneration.
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| Documents
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| Figures
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| Reference
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Harmer SC, Bicknell AB. Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis. Peptides. Oct 2005; 26(10): 1944-1951.
Mayorov AV, et al. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J. Med. Chem. Mar 2006; 49(6): 1946-1952.
Cai M, et al. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. J. Med. Chem. Mar 2005; 48(6): 1839-1848.
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Γ-1-Melanocyte Stimulating Hormone (MSH), Amide
