| Name
|
Α-Melanocyte-Stimulating Hormone (MSH), Amide
|
| Other Name
|
α-MSH, amidemelanotropinα-Melanocyte Stimulating Hormone; αMelanocyte Stimulating Hormone; a-Melanocyte Stimulating Hormone; aMelanocyte Stimulating Hormone; alpha-Melanocyte Stimulating Hormone; alphaMelanocyte Stimulating Hormone
|
| Sequence (Single letter abbreviations)
|
Ac-SYSMEHFRWGKPV-NH2
|
| Sequence（Three letter abbreviations）
|
Ac-{SER}{TYR}{SER}{MET}{GLU}{HIS}{PHE}{ARG}{TRP}{GLY}{LYS}{PRO}{VAL}-NH2
|
| C-
port
|
NH2
|
| Basic description
|
Alpha-MSH (alpha melanocyte-stimulating hormone) is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. ACTH has structural similarities to alpha-MSH. ACTH and alpha-MSH can induce grooming, stretching, yawning, penile erection responses in male rats, site of action in the brain and role of melanocortin receptors.
|
| The molecular weight
|
1664.900
|
| Chemical formula
|
C77H109N21O19S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed.
|
| N-
port
|
Ac
|
| Annotation
|
Alpha-MSH is derived from ACTH 1-13. Alpha-MSH is a hormone that stimulates melanogenesis and facilitates learning and memory. Alpha-MSH can affect inflammatory and immune responses and peripheral nerve regeneration.
|
| Documents
|
|
| Figures
|
|
| Reference
|
Yamaoka-Tojo M, et al. Central neurotranspeptide, alpha-melanocyte-stimulating hormone (alpha-MSH) is upregulated in patients with congestive heart failure. Intern. Med. Jul 2006; 45(7): 429-434.
Cragnolini AB, et al. Anxiety-like behavior induced by IL-1beta is modulated by alpha-MSH through central melanocortin-4 receptors. Peptides. Jun 2006; 27(6): 1451-1456.
Zhang XQ, et al. Effects of bFGF and alpha-MSH on adhesion and migration of human melanocytes in vitro. Zhejiang Da Xue Xue Bao Yi Xue Ban. Mar 2006; 35(2): 161-164.
|
Α-Melanocyte-Stimulating Hormone (MSH), Amide
