| Name
|
Β-Amyloid (25-35)
|
| Other Name
|
βAmyloid; b-Amyloid; bAmyloid; beta-Amyloid; betaAmyloid
|
| Sequence (Single letter abbreviations)
|
GSNKGAIIGLM
|
| Sequence（Three letter abbreviations）
|
{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}
|
| Basic description
|
Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
|
| Solubility
|
The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
|
| The molecular weight
|
1060.270
|
| Chemical formula
|
C45H81N13O14S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Fang F, Liu GT. Protective effects of compound FLZ on beta-amyloid peptide-(25-35)-induced mouse hippocampal injury and learning and memory impairment. Acta. Pharmacol. Sin. Jun 2006; 27(6): 651-658.
Mantha AK, et al. Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity. Biogerontology. Feb 2006; 7(1): 1-17.
|
Β-Amyloid (25-35)
