| Name
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Urotensin II, Human
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| Other Name
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U II UrotensinII; Urotensin 2; Urotensin2
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| Sequence (Single letter abbreviations)
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ETPDCFWKYCV
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| Sequence（Three letter abbreviations）
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{GLU}{THR}{PRO}{ASP}{CYS}{PHE}{TRP}{LYS}{TYR}{CYS}{VAL}
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| Chemical bridge
|
Cys5-Cys10
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| Basic description
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The orphan receptor GPR14 has been found to be expressed predominantly in cardiovascular tissue and many serve as a receptor for urotensin II (human). Urotensin II (human) binds with affinity to recombinant GPR14. It is found within both vascular and cardiac tissue. Urotensin II vasoconstrictive potency is reported to be an order of magnitude greater than that of endothelin-1 (ET-1), which would make it the more potent mammalian vasoconstrictor identified to date. Recently, our research data has shown that urotensin II is involved in the development of rat cardiac hypertrophy: Contractile response to human U II in rat and human pulmonary arteries was increased by endothelial factors, vascular tone, and the onset of pulmonary hypertension.
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| Solubility
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The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
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| The molecular weight
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1388.570
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| Chemical formula
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C64H85N13O18S2
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| The purity
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> 95%
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| Storage conditions
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Before use, store the peptide in the DRY form at 0°C - 5°C. For and more repeatable results, rehydrate the peptide immediately before use. Do not re-freeze any unused portions.
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| Annotation
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| Documents
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| Figures
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| Reference
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Rdzanek A, et al. Exercise urotensin II dynamics in myocardial infarction survivors with and without hypertension. Int. J. Cardiol. Jun 2006; 110(2): 175-178.
Gruson D, et al. Circulating urotensin II levels in moderate to severe congestive heart failure: Its relations with myocardial function and well established neurohormonal markers. Peptides. Jun 2006; 27(6): 1527-1531.
Albertin G, et al. Urotensin-II and UII-receptor expression and function in the rat adrenal cortex. Int. J. Mol. Med. Jun 2006; 17(6): 1111-1115.
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Urotensin II, Human
