| Name
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Tuftsin
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| Other Name
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| Sequence (Single letter abbreviations)
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TKPR
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| Sequence（Three letter abbreviations）
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{THR}{LYS}{PRO}{ARG}
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| Basic description
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Tuftsin is a physiologic tetrapeptide, which has been shown to possess immunoadjuvant properties including the stimulation of macrophage and granulocyte phagocytosis, migration, bactericidal, and tumoricidal activities. Tuftsin has also been reported to possess in vivo immunologically mediated anti-tumor potential. Some studies show that treatment of splenic effector cells with tuftsin prolongs the cytotoxic capabilities of these cells.
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| The molecular weight
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500.600
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| Chemical formula
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C21H40N8O6
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| The purity
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> 95%
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| Storage conditions
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Store tuftsin at -20°C. Keep container tightly closed.
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| Annotation
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Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, that resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin originates from a specific fraction of the parent protein through enzymatic processing. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts these effects on phagocytic cells, notably on macrophages.
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| Documents
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| Figures
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| Reference
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Nunn AD, et al. Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor. J. Biol. Chem. Mar 2006; 281(9): 5702-5710.
Misra CK, et al. The immunomodulatory effects of tuftsin on the non-specific immune system of Indian Major carp, Labeo rohita. Fish Shellfish Immunol. May 2006; 20(5): 728-738.
Aarons RJ, et al. A luminescent probe containing a tuftsin targeting vector coupled to a terbium complex. Chem. Commun. (Camb). Feb 2006; (8): 909-911.
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Tuftsin
