| Name
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Thyrotropin-Releasing Hormone (TRH)
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| Other Name
|
L-Pyroglutamyl-L-histidyl-L-prolinamideThyroliberin
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| Sequence (Single letter abbreviations)
|
pEHP-NH2
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| Sequence（Three letter abbreviations）
|
{pGLU}{HIS}{PRO}-NH2
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| C-port
|
NH2
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| Basic description
|
Thyrotropin-releasing hormone (TRH) is a tripeptide hormone secreted by the hypothalamus that stimulates the release of thyrotropin. This tripeptide is involved in the regulation of the hypothalamic pituitary-thyroid axis; it stimulates the synthesis and release from the anterior pituitary of thyrotropin (TSH) and prolactin.
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| Solubility
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The peptide is soluble in water to 10 mg/ml, appearing clear and colorless.
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| The molecular weight
|
362.380
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| Chemical formula
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C16H22N6O4
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| The purity
|
> 95%
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| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed.
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| Annotation
|
TRH and phorbol esters stimulate sphingomyelin synthesis in GH3 pituitary cells.
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| Documents
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| Figures
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| Reference
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Kirchberger NM, et al. Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit. J. Physiol. Feb 2006; 571(Pt 1): 27-42.
Soysal S, et al. The basal and TRH stimulated levels of prolactin in low risk climacteric patients with increased breast density: A matched pair case control trial. Maturitas. May 2006; 54(2): 103-109.
Pekary AE, et al. Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone. Neurochem. Int. Feb 2006; 48(3): 208-217.
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Thyrotropin-Releasing Hormone (TRH)
