| Name
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Thrombin Receptor Agonist
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| Other Name
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HIV-1 TAT Protein Peptide; HIV1 TAT Protein PeptideHIV-1 TAT; HIV1 TAT
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| Sequence (Single letter abbreviations)
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SFLLRNPNDKYEPF
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| Sequence（Three letter abbreviations）
|
{SER}{PHE}{LEU}{LEU}{ARG}{ASN}{PRO}{ASN}{ASP}{LYS}{TYR}{GLU}{PRO}{PHE}
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| Basic description
|
A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for Ca2+ mobilization, and both agonists induced Ca2+ release exclusively from internal stores. Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40,000 Da, 42,000 Da, 70,000 Da, 120,000 Da and 130,000 Da. There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
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| The molecular weight
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1739.900
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| Chemical formula
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C81H118N20O23
|
| The purity
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> 95%
|
| Storage conditions
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Store at -20°C.
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| Annotation
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| Documents
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| Figures
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| Reference
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Smith SA, et al. Polyphosphate modulates blood coagulation and fibrinolysis. Proc.Natl.Acad.Sci.USA. Jan 2006; 103(4): 903-908.
Monroe DM, Hoffman M. What does it take to make the perfect clot. Arterioscler Thromb Vasc Biol. Jan 2006; 26(1): 41-48.
Suzuki-Inoue K, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. Jan 2006; 107(2): 542-549.
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Thrombin Receptor Agonist
