| Name
|
Syntide 2
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
PLARTLSVAGLPGKK
|
| Sequence（Three letter abbreviations）
|
{PRO}{LEU}{ALA}{ARG}{THR}{LEU}{SER}{VAL}{ALA}{GLY}{LEU}{PRO}{GLY}{LYS}{LYS}
|
| Basic description
|
The native peptide PLARTLSVAGLPGKK is a selective substrate for CaM kinase II and PKC. It is also a poor substrate for phosphorylase kinase and is not phosphorylated by myosin light chain kinase. The sequence of PLARTLSVAGLPGKK is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the peptide for different kinases are 100 for CaMK II, 22 for PKC, 2 for phosphorylase kinase, and 0.5 for myosin light chain kinase, respectively.
|
| Solubility
|
Soluble in water: clear, colorless, 1 mg/ml H2O
|
| The molecular weight
|
1507.820
|
| Chemical formula
|
C68H122N20O18
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
K Barcomb., etc. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013 Sep;84(6):834-43.
|
Syntide 2
