| Name
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Substance P
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| Other Name
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|
| Sequence (Single letter abbreviations)
|
RPKPQQFFGLM-NH2
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| Sequence（Three letter abbreviations）
|
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}-NH2
|
| C-port
|
NH2
|
| Basic description
|
Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents.
|
| Solubility
|
Soluble in water (1 mg/ml)
|
| The molecular weight
|
1347.630
|
| Chemical formula
|
C63H98N18O13S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed.
|
| Annotation
|
HIV-I TAT Protein Peptide
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| Documents
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| Figures
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| Reference
|
Wick EC, et al. Transient receptor potential vanilloid 1, et al. calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. May 2006;290(5):G959-969.
Allen JW, et al. Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs. Toxicol Sci. May 2006;91(1):286-298.
Lindenburg PW., et al. On-line large-volume electroextraction coupled to liquid chromatography–mass spectrometry to improve detection of peptides. J Chromatogr A. 2012 Aug;124917-24.
|
Substance P
