| Name
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Somatostatin
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| Other Name
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| Sequence (Single letter abbreviations)
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AGCKNFFWKTFTSC
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| Sequence（Three letter abbreviations）
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{ALA}{GLY}{CYS}{LYS}{ASN}{PHE}{PHE}{TRP}{LYS}{THR}{PHE}{THR}{SER}{CYS}
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| Chemical bridge
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Cys3-Cys14
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| Basic description
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Somatostatin is a polypeptide hormone produced chiefly by the hypothalamus. It inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin. Somatostatin is a hormone comprising two peptides, one built of 14 amino acids, the other of 28 amino acids. Somatostatin is secreted not only by cells of the hypothalamus but also by delta cells of stomach, intestine, and pancreas. It binds to somatostatin receptors. Somatostatin was first discovered in hypothalamic extracts and identified as a hormone that inhibited secretion of growth hormone. Subsequently, somatostatin was found to be secreted by a broad range of tissues, including those of the pancreas, intestinal tract, and regions of the central nervous system outside the hypothalamus.
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| Solubility
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The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
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| The molecular weight
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1637.880
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| Chemical formula
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C76H104N18O19S2
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| The purity
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> 95%
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| Storage conditions
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Store the peptide at -20°C。
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| Annotation
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Somatostatin is a hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
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| Documents
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| Figures
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| Reference
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Gao F, Hu XF. Effect of somatostatin analogue octreotide injected into the third cerebral ventricle on pentagastrin-induced gastric acid secretion in rats. J. Gastroenterol. May 2006; 12(17): 2767-2769.
Ma Y, et al. Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice. J. Neurosci. May 2006; 26(19): 5069-5082.
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Somatostatin
