| Name
|
Phe-Met-Arg-Phe, Amide
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| Other Name
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F-M-R-F;-amide; Phe-Met-Arg-Phe amideMolluscan cardioexcitatory neuropeptide
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| Sequence (Single letter abbreviations)
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FMRF-NH2
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| Sequence（Three letter abbreviations）
|
{PHE}{MET}{ARG}{PHE}-NH2
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| C-port
|
NH2
|
| Basic description
|
FMRF-amide belongs to Molluscan Cardioexcitatory Neuropeptide. This peptide appears to localize with neuropeptide Y in some regions of the brain. FMRF-amide inhibits Na+-Ca2+ exchange in cardiac sarcolemma vesicles. The neuropeptide FMRF-amide stimulated enzyme activity 7- to 8-fold (EC50, 1 mM) via receptors that were pharmacologically distinct from those for dopamine and serotonin. FMRF- amide augmented cyclic AMP levels in slices of gill tissue with a time course similar to that for adenylate cyclase activation.
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| solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
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598.760
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| Chemical formula
|
C29H42N8O4S1
|
| The purity
|
> 95%
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| Storage conditions
|
Store at -20°C
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| Annotation
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| Documents
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| Figures
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| Reference
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Twan WH, et al. The presence and ancestral role of gonadotropin-releasing hormone in the reproduction of scleractinian coral, Euphyllia ancora. Endocrinology. Jan 2006; 147(1): 397-406.
Yamanaka N, et al. Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori.J Biol Chem. Apr 2005; 280(15): 14684-14690.
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Phe-Met-Arg-Phe, Amide
