| Name
|
PGLa
|
| Other Name
|
Golyglycolic acid
|
| Sequence (Single letter abbreviations)
|
GMASKAGAIAGKIAKVALKAL-NH2
|
| Sequence（Three letter abbreviations）
|
{GLY}{MET}{ALA}{SER}{LYS}{ALA}{GLY}{ALA}{ILE}{ALA}{GLY}{LYS}{ILE} {ALA}{LYS}{VAL}{ALA}{LEU}{LYS}{ALA}{LEU}-NH2
|
| C-port
|
NH2
|
| Basic description
|
PGLa is an antibiotic peptide found in frog skin. As a member of the magainin family it assumes an amphiphilic α-helical structure upon membrane binding. The cationic peptide has a affinity for bacterial membranes and is able to permeabilize them.
|
| The molecular weight
|
1968.460
|
| Chemical formula
|
C88H162N26O22S
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C
|
| Annotation
|
|
| Documents
|
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| Figures
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| Reference
|
Strandberg E, et al. Solid-state NMR analysis of the PGLa peptide orientation in DMPC bilayers: structural fidelity of 2H-labels versus sensitivity of 19F-NMR. Biophys. J. Mar 2006; 90(5): 1676-1686.
Glaser RW, et al. Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR. Biophys. J. May 2005; 88(5): 3392-3397.
Kang HS, Han MH et al. Short-term outcome of intracranial aneurysms treated with polyglycolic acid/lactide copolymer-coated coils compared to historical controls treated with bare platinum coils: a single-center experience. AJNR Am J Neuroradiol. Sep 2005;26(8):1921-8.
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PGLa
