| Name
|
Orexin B, Human
|
| Other Name
|
|
| Sequence (Single letter abbreviations)
|
RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
|
| Sequence（Three letter abbreviations）
|
{ARG}{SER}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2
|
| C-port
|
NH2
|
| Basic description
|
Orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons. Orexin B stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.
|
| Solubility
|
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
|
| The molecular weight
|
2899.340
|
| Chemical formula
|
C123H212N44O35S1
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Haj-Dahmane S, Shen RY. The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. Jan 2005; 25(4): 896-905.
|
Orexin B, Human
