| Name
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Neuromedin B
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| Other Name
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| Sequence (Single letter abbreviations)
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GNLWATGHFM-NH2
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| Sequence（Three letter abbreviations）
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{GLY}{ASN}{LEU}{TRP}{ALA}{THR}{GLY}{HIS}{PHE}{MET}-NH2
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| C-port
|
NH2
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| Basic description
|
Neuromedin B is a mammalian Bombesin peptide that binds with affinity to the Neuromedin B Bombesin receptor. Bombesin-like peptide that is present in the mammalian central nervous system and gastrointestinal tract that has been implicated in the control of food intake, smooth muscle contraction, and thermoregulation. Neuromedin is also an autocrine growth factor in non-small cell lung cancer.
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| Solubility
|
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
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1132.300
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| Chemical formula
|
C52H73N15O12S1
|
| The purity
|
> 95%
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| Storage conditions
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Store at -20°C.
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| Annotation
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| Documents
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| Figures
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| Reference
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Oliveira KJ, et al. Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis. J. Mol. Endocrinol. Feb 2006; 36(1): 73-80.
Merali Z, et al. Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. Biol. Psychiatry. Apr 2006; 59(7): 594-602.
Matusiak D, et al. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. Am. J. Physiol Gastrointest Liver Physiol. Apr 2005; 288(4): G718-G728.
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Neuromedin B
