| Name
|
Neurokinin B
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| Other Name
|
NKB
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| Sequence (Single letter abbreviations)
|
DMHDFFVGLM-NH2
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| Sequence（Three letter abbreviations）
|
{ASP}{MET}{HIS}{ASP}{PHE}{PHE}{VAL}{GLY}{LEU}{MET}-NH2
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| C-port
|
NH2
|
| Basic description
|
Neurokinin B belongs to the tachykinin family. Neurokinin B may play an important role in the olfactory, gustatory, visceral, and neuroendocrine processing information. Neurokinin B is potent bronchioconstrictor and has neruomodulatory roles in various brain functions. Neurokinin B is a member of the tachykinin family of neuropeptides that also includes Substance P and Neurokinin A. These carboxyl terminal-amidated peptides are derived from two preprotachykinin genes - the PPT-A gene encodes the sequences of Substance P, Neurokinin A, and neuropeptide K and the PPT-B gene encodes the sequence of Neurokinin B. Neurokinin B stimulate the production of immunoglobulins in peripheral B lymphocytes, This conditional response to Neurokinin B is likely due NK-3 receptors present only following co-culture and activation.
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| Solubility
|
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
|
1210.420
|
| Chemical formula
|
C55H79N13O14S2
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| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C.
|
| Annotation
|
Novel mammalian Tachykinin in Porcine spinal cord.
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| Documents
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| Figures
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| Reference
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Cuadrado I, et al. Mapping of neurokinin b in the cat brainstem. Anat. Embryol. (Berl). Sep 2005; 210(2): 133-143.
Duarte CR, et al. Incongruent pattern of neurokinin B expression in rat and mouse brains. Cell Tissue Res. Jan 2006; 323(1): 43-51.
Krajewski SJ, et al. Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J. Comp. Neurol. Aug 2005; 489(3): 372-386.
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Neurokinin B
