| Name
|
Neurokinin A (4-10)
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| Other Name
|
NKA (4-10)
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| Sequence (Single letter abbreviations)
|
DSFVGLM-NH2
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| Sequence（Three letter abbreviations）
|
{ASP}{SER}{PHE}{VAL}{GLY}{LEU}{MET}-NH2
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| C-port
|
NH2
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| Basic description
|
A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.
|
| The molecular weight
|
766.900
|
| Chemical formula
|
C34H54N8O10S
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C.
|
| Annotation
|
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| Documents
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| Figures
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| Reference
|
Lynn P, et al. Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. J. Physiol. Apr 2005; 564(Pt 2): 589-601.
Myers AC, et al. A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial Ganglia neurons. Am. J. Respir. Crit. Care Med. Feb 2005; 171(3): 212-216.
Cao W, et al. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. J. Pharmacol. Exp. Ther. Jun 2006; 317(3): 1349-1355.
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Neurokinin A (4-10)
