| Name
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Neuropeptide FF Morphine Modulating Neuropeptide
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| Other Name
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NPFF
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| Sequence (Single letter abbreviations)
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FLFQPQRF-NH2
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| Sequence（Three letter abbreviations）
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{PHE}{LEU}{PHE}{GLN}{PRO}{GLN}{ARG}{PHE}-NH2
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| C-port
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NH2
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| Basic description
|
Neuropeptide FF (and neuropeptide AF, which is also derived from the same precursor) belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus. Neuropeptide FF (NPFF) is found at concentrations in the posterior pituitary, spinal cord, hypothalamus and medulla and is believed to be involved in pain modulation, opioid tolerance, cardiovascular regulation, memory and neuroendocrine regulation.
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| Solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
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1081.300
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| Chemical formula
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54H76N14O10
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| The purity
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> 95%
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| Storage conditions
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Before using, store the peptide in the DRY form at 0-5°C. For and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
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| Annotation
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May act as a paracrine/endocrine mediator in the neurohypophysis. Inhibits the effects of both endogenous and exogenous opiates.
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| Documents
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| Figures
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| Reference
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D'Este L, et al. Changes in neuropeptide FF and NPY immunohistochemical patterns in rat brain under heroin treatment. Brain. Res. Apr 2006; 1083(1): 151-158.
Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc. Natl. Acad. Sci. U S A. Jan 2006; 103(2): 466-471.
Goncharuk VD, et al. Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study. J. Comp. Neurol. Jun 2006; 496(4): 572-593.
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Neuropeptide FF Morphine Modulating Neuropeptide
