| Name
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Motilin, Human, Porcine
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| Other Name
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MLN
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| Sequence (Single letter abbreviations)
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FVPIFTYGELQRMQEKERNKGQ
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| Sequence（Three letter abbreviations）
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{PHE}{VAL}{PRO}{ILE}{PHE}{THR}{TYR}{GLY}{GLU}{LEU}{GLN}{ARG}{MET}{GLN}{GLU}{LYS}{GLU}{ARG}{ASN}{LYS}{GLY}{GLN}
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| Basic description
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Motilin is a 22-amino-acid peptide secreted by endocrinocytes in the mucosa of the proximal small intestine. Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. Motilin is an intestinal peptide that stimulates contraction of gut smooth muscle. The motilin receptor has not been cloned yet, but motilin-receptor agonists appear to be potent prokinetic agents for the treatment of dysmotility disorders. The nucleic classic sequence for human motilin shows seven differences between it and the cDNA coding for pig motilin, but the amino acid sequence deduced from both sequences is identical.
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| Solubility
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The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
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| The molecular weight
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2699.050
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| Chemical formula
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C120H188N34O35S1
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| The purity
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> 95%
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| Storage conditions
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Before use, store the peptide in the DRY form at 0°C - 5°C. For and more repeatable results, rehydrate the peptide immediately before use. Do not re-freeze any unused portions.
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| Annotation
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| Documents
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| Figures
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| Reference
|
Matsuura B, et al. Differential Contributions of Motilin Receptor Extracellular Domains for Peptide and Non-peptidyl Agonist Binding and Activity. J. Biol. Chem. May 2006; 281(18): 12390-12396.
Koenig JB, et al. Effect of intraluminal distension or ischemic strangulation obstruction of the equine jejunum on jejunal motilin receptors and binding of erythromycin lactobionate. Am. J. Vet. Res. May 2006; 67(5): 815-820.
Cuomo R, et al. Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways. Am. J. Gastroenterol. Apr 2006; 101(4): 804-811.
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Motilin, Human, Porcine
