| Name
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Mouse, Rat
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| Other Name
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MOG(35-55)
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| Sequence (Single letter abbreviations)
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MEVGWYRSPFSRVVHLYRNGK
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| Sequence（Three letter abbreviations）
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{MET}{GLU}{VAL}{GLY}{TRP}{TYR}{ARG}{SER}{PRO}{PHE}{SER}{ARG}{VAL}{VAL}{HIS}{LEU}{TYR}{ARG}{ASN}{GLY}{LYS}
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| Basic description
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Myelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes and has been implicated as an important autoantigen in multiple sclerosis (MS). This peptide induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
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| Solubility
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Recommended to reconstitute the lyophilized MOG in sterile 18 MΩ-cm H2O of not less than 100 µg/ml. This solution can then be further diluted to other aqueous solutions.
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| The molecular weight
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2581.980
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| Chemical formula
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C118H177N35O29S1
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C.
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| Annotation
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| Documents
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| Figures
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| Reference
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Komiyama Y, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. Jul 2006; 177(1): 566-573.
Teuscher C, et al. Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc. Natl. Acad. Sci. U.S.A. May 2006; 103(21): 8024-8029.
Bannerman PG, et al. Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. Brain. Aug 2005; 128(Pt 8): 1877-1886.
Kim KD., et al. Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation. J Immunol. 2014 Jan;192(1):110-22.
Heckman KL., et al. Custom Cerium Oxide Nanoparticles Protect Against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain. ACS Nano. 2013 Dec;7(12):10582-96.
Angiari S., et al. Regulatory T Cells Suppress the Late Phase of the Immune Response in Lymph Nodes through P-Selectin Glycoprotein Ligand-1. J Immunol. 2013 Dec;191(11):5489-500..
Kozela E., et al. Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype. J Neuroimmune Pharmacol. 2013 Dec;8(5):1265-76..
Aharoni R., et al. Magnetic Resonance Imaging Characterization Of Different Experimental Autoimmune Encephalomyelitis Models And The Therapeutic Effect Of Glatiramer Acetate. Exp Neurol. 2013 Feb;240130-44.
F Mairet alThy1 Sca1 innate lymphoid cells infiltrate the CNS during autoimmune inflammation, but do not contribute to the disease development. Eur J Immunol. 2013Sep;
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Mouse, Rat
