| Name
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Melanin Concentrating Hormone, Salmon
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| Other Name
|
MCH
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| Sequence (Single letter abbreviations)
|
DTMRCMVGRVYRPCWEV
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| Sequence（Three letter abbreviations）
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{ASP}{THR}{MET}{ARG}{CYS}{MET}{VAL}{GLY}{ARG}{VAL}{TYR}{ARG}{PRO}{CYS}{TRP}{GLU}{VAL}
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| Chemical bridge
|
Disulfide bridge: Cys5-Cys14
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| Basic description
|
Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key messenger in the regulation of food intake. An understanding of the biological actions of Melanin Concentrating Hormone has been so far hampered by the lack of information about its receptor(s) and their location in the brain. We recently identified the orphan G-protein-coupled receptor SLC-1 as a receptor for the neuropeptide Melanin Concentrating Hormone.
|
| The molecular weight
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2099.480
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| Chemical formula
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C89H139N27O24S4
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
Melanin Concentrating Hormone (MCH) is hypothalamic appetite stimulant and the ligand for somatostatin-like receptor 1(SLC-1).
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| Documents
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| Figures
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| Reference
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Fry D, et al. Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1). Int. J. Biochem. Cell Biol. Aug 2006; 38(8): 1290-1299.
Wu WL, et al. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med. Chem. Lett. Jul 2006; 16(14): 3674-3678.
Wu WL, et al. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg Med. Chem. Lett. Jul 2006; 16(14): 3668-3673.
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Melanin Concentrating Hormone, Salmon
