| Name
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IRBP (1-20), Human
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| Other Name
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| Sequence (Single letter abbreviations)
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GPTHLFQPSLVLDMAKVLLD
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| Sequence（Three letter abbreviations）
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{Gly}{Pro}{Thr}{His}{Leu}{Phe}{Gln}{Pro}{Ser}{Leu}{Val}{Leu}{Asp}{Met}{Ala}{Lys}{Val}{Leu}{Leu}{Asp}
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| Basic description
|
This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the interphotoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype. Immunization with IRBP (1 – 20) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU) disease. The pathology of disease induced by the peptide, or by adoptive transfer of cells specific to the peptide, is similar to that induced by the whole IRBP protein.
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| The molecular weight
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2194.600
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| Chemical formula
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C101H164N24O28S1
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| The purity
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> 95%
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| Storage conditions
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Store the peptide at -20°C.
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| Annotation
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| Documents
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| Figures
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| Reference
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Lee DJ., et al. Both MC5r and A2Ar Are Required for Protective Regulatory Immunity in the Spleen of Post–Experimental Autoimmune Uveitis in Mice. J Immunol. 2013 Qct;191(8):4103-11.
Darren J. Lee and Andrew W. Taylor.., et al. Following Eau Recovery There Is An Associated Mc5R-Dependent Apc Induction Of Regulatory Immunity In The Spleen. Invest Ophthalmol Vis Sci. 2011 Nov;52(12):8862-7
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IRBP (1-20), Human
