| Name
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Gastrin-Releasing Peptide, Human
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| Other Name
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|
| Sequence (Single letter abbreviations)
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VPLPAGGGTVLTKMYPRGNHWAVGHLM-NH2
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| Sequence（Three letter abbreviations）
|
{VAL}{PRO}{LEU}{PRO}{ALA}{GLY}{GLY}{GLY}{THR}{VAL}{LEU}{THR}{LYS}{MET}{TYR}{PRO}{ARG}{GLY}{ASN}{HIS}{TRP}{ALA}{VAL}{GLY}{HIS}{LEU}{MET}-NH2
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| C-port
|
NH2
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| Basic description
|
Gastrin-releasing peptide (GRP) is released by the post-ganglionic fibres of the vagus nerve, which innervate the G cells of the stomach and stimulate them to release gastrin. GRP can directly stimulate pepsinogen release from chief cells by a specific GRP receptor that mobilizes intracellular calcium. Gastrin-releasing peptide has a prominent role as a tumor marker in the diagnosis of small-cell lung carcinoma.
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| Solubility
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The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
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| The molecular weight
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2859.300
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| Chemical formula
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C130H204N38O31S2
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| The purity
|
> 95%
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| Storage conditions
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Store the peptide at -20°C. Keep container tightly closed.
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| Annotation
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| Documents
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| Figures
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| Reference
|
Grimsholm O, et al. Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res. Ther. 2005; 7(3): R416-426.
Martinez A, et al. Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. Oncogene. Jun 2005; 24(25): 4106-4113.
Brown TM, et al. Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling. J. Neurosci. Nov 2005; 25(48): 11155-11164.
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Gastrin-Releasing Peptide, Human
