| Name
|
Gly-Arg-Gly-Asp-Asn-Pro
|
| Other Name
|
GRGDNP; GLY-ARG-GLY-ASP-ASN-PRO
|
| Sequence (Single letter abbreviations)
|
GRGDNP
|
| Sequence（Three letter abbreviations）
|
{GLY}{ARG}{GLY}{ASP}{ASN}{PRO}
|
| Basic description
|
G-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM.
|
| The molecular weight
|
614.600
|
| Chemical formula
|
C23H38N10O10
|
| The purity
|
> 95%
|
| Storage conditions
|
Store at -20°C. Keep tightly closed. Store in a cool dry place.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Sarin V, et al. Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha 5 beta 1 integrin. J. Physiol. Apr 2005; 564(Pt 2): 603-617.
|
Gly-Arg-Gly-Asp-Asn-Pro
