| Name
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Eptifibatide
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| Other Name
|
Integrilin
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| Sequence (Single letter abbreviations)
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| Sequence（Three letter abbreviations）
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MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2
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| C-port
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NH2
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| Chemical bridge
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Mpa1-Cys7
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| Basic description
|
Eptifibatide is a cyclic heptapeptide containing six amino acids and one mercaptopropionyl (des-amino cysteinyl) residue. An interchain disulfide bridge is formed between the cysteine amide and the mercaptopropionyl moieties. Chemically it is N6 -(aminoiminomethyl)-N2 -(3-mercapto-1-oxopropyl-L- lysylglycyl-L-a-aspartyl- L-tryptophyl-L -prolyl-L-cysteinamide, cyclic (1Ø6)-disulfide. Eptifibatide binds to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets and inhibits platelet aggregation
|
| The molecular weight
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831.960
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| Chemical formula
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C35H19N11O9S2
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| The purity
|
> 95%
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Reference
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Coons JC, Barcelona RA et al. Eptifibatide-associated acute, profound thrombocytopenia. Ann Pharmacother. Feb 2005;39(2):368-72.
Gurbel PA, Bliden KP et al. Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation. Mar 2005;111(9):1153-9
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Eptifibatide
