| Name
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Endomorphin-1
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| Other Name
|
Endomorphin1; EM-1; EM1
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| Sequence (Single letter abbreviations)
|
YPWF-NH2
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| Sequence（Three letter abbreviations）
|
{TYR}{PRO}{TRP}{PHE}-NH2
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| C-port
|
NH2
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| Basic description
|
Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
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| Solubility
|
The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
|
| The molecular weight
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610.700
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| Chemical formula
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C34H38N6O5
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| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed.
|
| Annotation
|
Endomorphin-1 is a potent, selective endogenous μ opioid receptor agonist.
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| Documents
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| Figures
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| Reference
|
Botros M, et al. Endomorphin-1 and endomorphin-2 differentially interact with specific binding sites for substance P (SP) aminoterminal SP(1-7) in the rat spinal cord.. Peptides. Apr 2006; 27(4): 753-739.
Okutsu H, et al. Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology. Feb 2006; 31(2): 375-383.
Leng DN, et al. Endomorphin-1 is more potent than endomorphin-2 in inhibition of synaptic transmission in substantia gelatinosa of adult rat spinal cord. Int. J. Neurosci. Nov 2005; 115(11): 1515-1526.
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Endomorphin-1
