| Name
|
Calcitonin Gene Related Peptide (CGRP) (8-37), Human
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| Other Name
|
α-CGRP 8-37CGRP (8-37), human
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| Sequence (Single letter abbreviations)
|
VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2
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| Sequence（Three letter abbreviations）
|
{VAL}{THR}{HIS}{ARG}{LEU}{ALA}{GLY}{LEU}{LEU}{SER}{ARG}{SER}{GLY}{GLY}{VAL}{VAL}{LYS}{ASN}{ASN}{PHE}{VAL}{PRO}{THR}{ASN}{VAL}{GLY}{SER}{LYS}{ALA}{PHE}-NH2
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| C-port
|
NH2
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| Basic description
|
Calcitonin-Gene-Related Peptide (CGRP) (8-37) inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats. The present study was performed to explore the effect of CGRP (8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. CGRP (8-37) was applied directly on the dorsal surface of the L3 to L5 spinal cord. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord.
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| Solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| The molecular weight
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3125.590
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| Chemical formula
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C139H230N44O38
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| The purity
|
> 95%
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| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed. Store with desiccant.
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| Annotation
|
Calcitonin-Gene-Related Peptide (CGRP) (8-37) is a selective antagonist for CGRP receptors and an agonist for calcitonin receptors.
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| Documents
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| Figures
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| Reference
| Kawase T, et al. Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)(2,7)] calcitonin gene-related peptide and CGRP(8-37). Am. J. Physiol., Cell Physiol. Oct 2005; 289(4): C811-818.
HIV-I TAT Protein Peptide
Calcitonin Gene Related Peptide (CGRP) (8-37), Human
