| Name
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C-Peptide (3-33), Human
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| Other Name
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| Sequence (Single letter abbreviations)
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EAEDLQVGQVELGGGPGAGSLQPLALEGSLQ
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| Sequence（Three letter abbreviations）
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{GLU}{ALA}{GLU}{ASP}{LEU}{GLN}{VAL}{GLY}{GLN}{VAL}{GLU}{LEU}{GLY}{GLY}{GLY}{PRO}{GLY}{ALA}{GLY}{SER}{LEU}{GLN}{PRO}{LEU}{ALA}{LEU}{GLU}{GLY}{SER}{LEU}{GLN}
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| Basic description
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C-Peptide is a byproduct of insulin production, usually by the pancreas. The level of C-peptide can be used as a gauge of how much insulin is being produced in the body. The amount of C-peptide in the blood can indicate the presence or absence of disease. Abnormally low amounts of C-peptide in the blood suggest that insulin production is too low or absent because of type I diabetes, also known as juvenile or insulin-dependent diabetes. Abnormally amounts of C-peptide warn of the possible presence of insulinoma tumors, which secrete insulin.
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| Solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out any smaller portion of the contents.
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| The molecular weight
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3020.260
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| Chemical formula
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C129H211N35O48
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| The purity
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> 95%
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| Storage conditions
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Store at -20°C. Keep container tightly closed.
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| Annotation
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| Documents
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| Figures
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| Reference
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Kobayashi Y, et al. Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in -glucose conditions. Diabetologia. Nov 2005; 48(11): 2396-2401.
Rogatsky E, et al. Sensitive quantitative analysis of C-Peptide in human plasma by 2-dimensional liquid chromatography-mass spectrometry isotope-dilution assay. Clin. Chem. May 2006; 52(5): 872-879.
Munte CE, et al. Solution structure of human proinsulin C-peptide. FEBS J. Aug 2005; 272(16): 4284-4293.
AW Giebink., etc. C-Peptide Stimulated Nitric Oxide Production In A Cultured Pulmonary Artery Endothelium Is Erythrocyte-Mediated And Requires Zn2+. Diabetes Metab Res Rev. 2013 Jan;29(1):44-52.
Borer-Weir KE., etc. Evaluation of a commercially available radioimmunoassay and species-specific ELISAs for measurement of concentrations of insulin in equine serum. Am J Vet Res. 2012 Qct;73(10):159
Landreh M., etc. Proinsulin C-peptide interferes with insulin fibril formation. Biochem Biophys Res Commun. 2012 Feb;418(3):489-93.
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C-Peptide (3-33), Human
