| Name
|
Bactenecin, Bovine
|
| Sequence (Single letter abbreviations)
|
RLCRIVVIRVCR
|
| Sequence（Three letter abbreviations）
|
{ARG}{LEU}{CYS}{ARG}{ILE}{VAL}{VAL}{ILE}{ARG}{VAL}{CYS}{ARG}
|
| Chemical bridge
|
Disulfide bridge: Cys3-Cys11
|
| Basic description
|
Bactenecin is an antimicrobial peptide isolated from bovine neutrophils. Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide-bonded form. The peptide inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum. Acetylation and amidation of the amino- and carboxy-termini of bactenecin do not change its potency, while replacement of its two cysteine residues with serine decreases potency.
|
| The molecular weight
|
1483.900
|
| Chemical formula
|
C63H118N24O13S2
|
| The purity
|
> 95%
|
| Storage conditions
|
Store the peptide at -20°C. Keep container tightly closed.
|
| Annotation
|
|
| Documents
|
|
| Figures
|
|
| Reference
|
Huang LC, et al. Multifunctional Roles of Human Cathelicidin (LL-37) at the Ocular Surface. Invest. Ophthalmol. Vis. Sci. Jun 2006; 47(6): 2369-2380.
Bergen PJ, et al. Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa. Antimicrob. Agents Chemother. Jun 2006; 50(6): 1953-1958.
Lau YE, et al. Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37. Am. J. Respir. Cell Mol. Biol. Apr 2006; 34(4): 399-409.
|
Bactenecin, Bovine
