| Name
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Bradykinin (1-5)
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| Other Name
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| Sequence (Single letter abbreviations)
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RPPGF
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| Sequence（Three letter abbreviations）
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{ARG}{PRO}{PRO}{GLY}{PHE}
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| Basic description
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The bradykinin (BK) fragment (1-5) (RPPGF) is among the more stable of naturally occurring metabolites. Bradykinin (1-5) may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for certain biological activities. BK 1-5 is the smallest peptide that can inhibit α-thrombin-induced platelet aggregation and secretion and calcium mobilization. Bradykinin (1-5) also prevents α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.
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| The molecular weight
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572.660
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| Chemical formula
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C27H40N8O6
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| The purity
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> 95%
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| Storage conditions
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Store the peptide at -20°C
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| Annotation
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| Documents
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| Figures
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| Reference
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Dielis AW, et al. The prothrombotic paradox of hypertension: role of the renin-angiotensin and kallikrein-kinin systems. Hypertension. Dec 2005; 46(6): 1236-1242.
Wu TJ, et al. Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5). Endocrinology. Jan 2005; 146(1): 280-286.
Nieman MT, et al. Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4. FEBS Lett. Jan 2005; 579(1): 25-29.
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Bradykinin (1-5)
