| Name
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Adrenomedullin (AM) (22-52), Human
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| Other Name
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| Sequence (Single letter abbreviations)
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TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
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| Sequence（Three letter abbreviations）
|
{THR}{VAL}{GLN}{LYS}{LEU}{ALA}{HIS}{GLN}{ILE}{TYR}{GLN}{PHE}{THR}{ASP}{LYS}{ASP}{LYS}{ASP}{ASN}{VAL}{ALA}{PRO}{ARG}{SER}{LYS}{ILE}{SER}{PRO}{GLN}{GLY}{TYR}-NH2
|
| C-port
|
NH2
|
| Basic description
|
Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin. ADM is produced in peripheral tissues, adrenal medulla, lung, and kidney. ADM has specific receptors on astrocytes and it is unregulated in ischaemia.
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| Solubility
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
|
| The molecular weight
|
3576.100
|
| Chemical formula
|
C159H252N46O48
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| The purity
|
> 95%
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| Storage conditions
|
Before using, store the peptide in the DRY form at - 20°C. For and repeatable results, rehydrate the peptide immediately before using. The peptide is stable under 4 °C for three days once reconstituted. Do not re-freeze any unused portions.
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| Documents
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| Figures
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| Reference
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Hashimoto H, et al. Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in rats. Am. J. Physiol. Endocrinol. Metab. Nov 2005; 289(5): E753-E761.
Ross GR, Yallampalli C. Endothelium-Independent Relaxation by Adrenomedullin in Pregnant Rat Mesenteric Artery: Role of cAMP-Dependent Protein Kinase A and Calcium-Activated Potassium Channels. J. Pharmacol. Exp. Ther. Jun 2006; 317(3): 1269-1275.
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Adrenomedullin (AM) (22-52), Human
