Basic description
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The synucleins, including alpha-synuclein (also designated NACP for nonamyloid component precursor),beta-synuclein (also designated PNP 14 for phospho-neuroprotein 14)and gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. alpha-synuclein, a component of Alzheimer’s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of alpha-synucleinand beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson’s disease, a mutant form of alpha-synuclein has been found and gamma-synuclein is associated with axonal pathology.
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