| Name
|
Rabbit Anti-APOJ Antibody
|
| Basic description
|
Apolipoprotein J is the major secreted product of Sertoli cells and is thought to play a critical role in spermatogenesis. The protein was shown to be a normal constituent of human blood and is also thought to be a control mechanism of the complement cascade. It prevents the binding of a C5b-C7 complex to the membrane of the target cell and in this way inhibits complement-mediated cytolysis.
Apolipoprotein J is overexpressed in human prostate and breast cancers and in squamous cell carcinomas. Suppression of Apolipoprotein J renders these cells sensitive to chemotherapeutic drug-mediated apoptosis. It has been proposed that elevated levels of Apolipoprotein J may promote oncogenic transformation and tumor progression by interfering with BAX proapoptotic activities.
|
| Character
|
Lyophilized or Liquid
|
| Purification methods
|
affinity purified by Protein A or Protein G
|
| Storage of liquid
|
0.01M PBS(pH7.4) with 1% BSA。
|
| Storage conditions
|
Store at -20°C.
|
| Subtypes
|
IgG
|
Rabbit Anti-APOJ Antibody/载脂蛋白J抗体
