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Name	Rabbit Anti-ASIC1 Antibody
Basic description	Cation channel with affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Character	Lyophilized or Liquid
Purification methods	affinity purified by Protein A or Protein G
Storage of liquid	0.01M PBS(pH7.4) with 1% BSA。
Storage conditions	Store at -20°C.
Subtypes	IgG