| Name
|
Rabbit Anti-Axin 2 Antibody
|
| Basic description
|
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
|
| Character
|
Lyophilized or Liquid
|
| Purification methods
|
affinity purified by Protein A or Protein G
|
| Storage of liquid
|
0.01M PBS(pH7.4) with 1% BSA。
|
| Storage conditions
|
Store at -20°C.
|
| Subtypes
|
IgG
|
Rabbit Anti-Axin 2 Antibody/轴抑制蛋白2抗体
