| Name
|
Rabbit Anti-ApoER2 Antibody
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| Chinese name
|
载脂蛋白E2受体抗体
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| Basic description
|
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has er affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. ly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
|
| Antibody type
|
rabbit polyclonal antibodies
|
| Immune to the original
|
Coupling peptides or recombinant protein
|
| Concentration
|
1mg/ml
|
| Storage conditions
|
Store at -20°C.
|
| Subtypes
|
IgG
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| Composition
|
Affinity purification，0.01M PBS(pH7.4)，1% BSA
|
| Application
|
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500
IF=1:100-500
optimal dilutions/concentrations should be determined by the end user.
|
Rabbit Anti-ApoER2 Antibody/载脂蛋白E2受体抗体
