目录多肽

名称 ω-Conotoxin GVIA|omega-ConoGVIAn GVIA
编码 [106375-28-4]
别名 ω-Conotoxin GVIA|omega-ConoGVIAn GVIA
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） CKS(Hyp)GSSCS(Hyp)TSYNCCRSCN(Hyp)YTKRCY-NH2(Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)
序列（三字母缩写） H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2?(trifluoroacetate salt)(Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)
基本描述 Reversible N-type Ca2+ Channel Blocker W-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitve Ca2+ channels in neurons. It has been used to identify different Ca2+ channel subtypes in amphibian brain.
溶解度
分子量 3037.39
化学式 C120H182N38O43S6
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
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Reference Rivier, J. et al. J. Biol. Chem. 262, 1194 (1987) Lampe, RA. et al. Biochem. 32, 3255 (1993) Wright, C. and JA. Angus, J. Cardiovasc. Pharmacol. 30, 392 (1997) Serone, A. and JA. Angus, Br. J. Pharmacol. 127, 927 (1999). B.M. Olivera, J.M. Mclntosh, L.J. Cruz, F.A. Luque, and W.R. Gray, Biochemistry, 23, 5087 (1984). (Original) Y. Nishiuchi, K. Kumagaye, Y. Noda, T.X. Watanabe, and S. Sakakibara, Biopolymers, 25, S61 (1986). (Chem. Synthesis and S-S Bond) B.M.Olivera et al., Biochemistry, 23, 5087 (1984) B.M.Olivera et al., Biochemistry, 26, 2086 (1987) J.Rivier et al., J. Biol. Chem., 262, 1194 (1987) D.R.Hillyard et al., Neuron, 9, 69 (1992) K.Sato et al., Biochem. Biophys. Res. Commun., 194, 1292 (1993) J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994)
C端
N端
化学桥 (Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)

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