| 名称
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Amyloid beta/A4 Protein Precursor770 (740-
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| 编码
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| 别名
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Amyloid beta/A4 Protein Precursor770 (740-
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| 纯度
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80%，90%，95%，98%，99%
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| 重量
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1mg,5mg,10mg,50mg,100mg,1g
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| 序列（单字母缩写）
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AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| 序列（三字母缩写）
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H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH (trifluoroacetate salt)
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| 基本描述
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This peptide is the English (H6R) mutation of beta-amyloid, which accelerates fibrillation without increasing protofibril formation. The English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His6 by Arg influences the structure of the Cu2+ complex formed by Abeta peptides.
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| 溶解度
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| 分子量
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3717.12
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| 化学式
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C162H243N45O52S2
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| 存储条件
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| 注释
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| Documents
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| Figures
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| Reference
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D.C.Lu et al., Nat. Med., 6, 397 (2000)
C.Dumanchin-Njock et al., J. Neurochem., 78, 1153 (2001)
V.Galvan et al., J. Neurochem., 82, 283 (2002)
Y.Chen et al., J. Cell Biol., 163, 27 (2003)
D.C.Lu et al., J. Neurochem., 87, 733 (2003)
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| C端
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| N端
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| 化学桥
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