| 名称
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Amyloid beta/A4 Protein Precursor770 (135-
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| 编码
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[315229-44-8]
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| 别名
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Amyloid beta/A4 Protein Precursor770 (135-
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| 纯度
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80%，90%，95%，98%，99%
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| 重量
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1mg,5mg,10mg,50mg,100mg,1g
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| 序列（单字母缩写）
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FLHQERMDVCETHLHWHTVAK
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| 序列（三字母缩写）
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H-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH (trifluoroacetate salt)
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| 基本描述
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This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid beta-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid beta-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
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| 溶解度
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| 分子量
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2618
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| 化学式
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C116H173N35O31S2
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| 存储条件
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| 注释
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| Documents
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| Figures
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| Reference
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G.Multhaup et al., Science, 271, 1406 (1996)
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| C端
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| 化学桥
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