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名称 |
Rat VEGFR3 / FLT-4 Protein/重组大鼠 VEGFR3 / FLT-4
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规格 |
20ug
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编号 |
CZDB-009
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价格 |
询价
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中文名 |
Rat VEGFR3 / FLT-4 Protein/重组大鼠 VEGFR3 / FLT-4
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分子别称 |
Chy, Flt-4, VEGFR-3, VEGFR3
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分子种属 |
Mouse
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表达标签 |
His，S
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表达宿主 |
E. coli
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浓度 |
> 95 % as determined by SDS-PAGE
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缓冲液 |
Lyophilized from sterile PBS, pH 7.4
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存储条件 |
-70°C，应避免反复冻融。
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基本描述 |
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
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