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Β-Amyloid (22-35)
| 名称
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Β-Amyloid (22-35)
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| 别名
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Beta-Amyloid (22-35)
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| 序列（单字母缩写）
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EDVGSNKGAIIGLM
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| 序列（三字母缩写）
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{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}
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| 基本描述
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Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. It has been demonstrated that beta amyloid (22-35) possesses a cytotoxic effect on cultured rat hippocampus neurons in serum-free medium. Aggregates and typical amyloid fibrils resembling those of the beta amyloid protein (AP) are formed in neutral buffer solution from beta amyloid (22-35). These fibrils show characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta amyloid (22-35) can be suppressed by addition of calf serum, dibutyryl cAMP, or insulin to the culture medium. However, the addition of NGF or substance P will not suppress the neurotoxicity. Beta amyloid (22-35) does not act on glial cells. These results suggest that AP can induce neurotoxicity in hippocampal cells in vitro and may result in a disorder involving intracellular signal transduction.
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| 溶解度
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Soluble in water.
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| 分子量
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1403.610
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| 化学式
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C59H102N16O21S
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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