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产品  
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 Β-Amyloid (1-42), Human
| 名称
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Β-Amyloid (1-42), Human
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| 别名
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| 序列（单字母缩写）
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DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
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| 序列（三字母缩写）
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{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}{GLY}{SER} {ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL}{ILE}{ALA}
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| 基本描述
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This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors. |
| 溶解度
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Soluble in water
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| 分子量
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4514.100
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| 化学式
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C203H311N55O60S1
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C
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| Documents
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| Reference
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Ambroggio EE, et al. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. Apr 2005; 88(4): 2706-2713.
Mathew A., etc. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One. 2012 Mar;7(3):e32616.
R Banerjee. etc. Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;
Anila Mathew etc. Amyloid-Binding Aptamer Conjugated Curcumin-PLGA Nanoparticle for Potential Use in Alzheimer’s Disease. BioNanoScience. 2012 Jun; 2 (2); 83-93.
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